You have an IDEA, we make IT GROW ...LITERALY
What We Do

WHAT WE DO

More than 25 years growing a great range of microorganism and over 15 years of experience in microbial manufacturing.

Our team, specialized in the optimization and scale-up of laboratory, have completed hundreds of processes for different applications and from different levels of initial development into industrial processes for bacteria, actinomycetes or fungi to produce different products: biomass, proteins, or small molecules.

PROCESS DEVELOPMENT

Process development
  • Rapid Project Assesment
  • Cell Bank Storage and Maintenance
  • Strain Optimization
  • Media Optimization
  • Fermentation Optimization for Bacteria, Actinomycetes, Fungi and Yeast
  • DSP Development from biomass recovery to small molecules purification
  • Wide analytical Techniques in house: microbiology, NMR and HR-MS
  • Other services

BIOPROCESS SCALE-UP

Bioprocess Scale-up
  • Proof-of-concept from lab scale to semi-industrial
  • Viability studies
  • Bioprocesses concept design
  • Downscale Studies
  • Efficient Tech Transfer System
  • Production for efficacy tests

CUSTOM MANUFACTORING

Custom Manufactoring
  • GMP & non GMP productions
  • Numerous process monitoring and control options
  • Batch Manufacturing for different industries
  • Wide range of product type:
    biomass, proteins, extracts and highly pure small molecules
  • Several available techniques:
    solid preparation, micro and ultrafiltration, homogenization, precipitation/crystalization, solvent extraction, chromatography, etc.
  • Grams to kilograms productions

FACILITIES

Our new facilities fill the gap between the laboratory and the industry, with a fully equiped pilot plant specialized in optimizing and scaling up fermentation processes that allows us to cover in house volumes up to 3 m3.

  • Raw material warehouse
  • Dispensing area
  • Inocula preparation room
  • QC Laboratory: microbiology and physico-chemical
  • ATEX processing area
  • Clean Room
  • Intermediate and Final Product storage areas

750 m2 fully dedicated to GMP fermentation

Equipment

EQUIPMENT

More than 25 years growing a great range of microorganisms and over 15 years of experience in microbial fermentation manufacturing.

Our team, specialized in the optimization and scale-up of laboratory, have completed hundreds of processes for different applications and
from different

MAIN EQUIPMENT:

  • Twin fermenter (2 X 5L cultivation vessels)
  • 30L bioreactor
  • 300L bioreactor
  • 3000L bioreactor
  • 3 orbital shakers
  • 1700L feed tank
  • 1 harvest / storage tank

Fermenters include monitoring and control technology for: antifoam, shaking, areation, temperature, pressure, pH, dissolved oxygen concentration and CO2 production.

AUXILIARY EQUIPMENT:

  • 80ºC freezing cabinet
  • 80ºC liquid nitrogen cabinet freezer
  • Up to 8 kg capacity autoclave
  • Laminar flow cabin
  • Optical microscopy
  • 2 incubation ovens
  • pH meter
  • Spectrophotometer
  • Microtubes centrifuge
  • 3L centrifuge (4 x 750ml)
  • HPLC
  • HPLC-MS
  • RMN
  • Refractometer

MAIN EQUIPMENT:

  • Centrifuge
  • Up to 30L scale tangential filter
  • Up to 3000L scale tangencial filter
  • Homogenizer

ATEX AREA

  • 2000L Nutsche filter
  • 600L and 1600 L settling vessels
  • BÜCHI R-220 Rotary evaporator
  • Batch evaporation reactors
  • 2 Solvent recovery tanks
  • MPLC Chromatography
  • Crystallizer
  • Nutsche Glass filter (90L)

CLEAN ROOM

  • Controlled environment. Overpressure system
  • Walk-In fume cabinet
  • Büchi B-100 Rotary evaporator
  • Vacuum oven

R&D

  • Büchi B-100 Rotary evaporator
  • HPLC
  • HPLC-MS
  •  In-house NMR service

CLEAN ROOM
R&D

UTILITIES:

  • High pressure compressed air
  • Demineralized process water
  • Vacuum system
  • Laminar flow cabin
  • Nitrogen gas
  • Oxigen gas
  • Steam

SERVICES:

  • Supply chain
  • Raw material storage
  • Solvents storage

EXPERT TEAM

Antonio

Antonio Fernández, PhD

Scientific Director

CEO of Biomar since 2002. PhD from the MD Anderson Cancer Center in Houston. Scientist at the Dana-Farber Cancer Institute and the Children's Hospital of Boston. Surgical Research Laboratories.

Rubén Álvarez PhD.

Rubén Álvarez PhD

Head of Production Plant

Industrial fermentation expert. 10+ years experience in bioprocess from 5 to 220.000L, with a wide range of microorganisms, such as: filamentous fungi, yeasts,microalgae, enterobacteria and actinomycetes among others.

Javi

Javier Marcos

Pilot Plant Coordinator

DSP Specialist. More than 35 years of work experience in Biotech Manufacturing Plants.

Pilot Plant safety expert.

Carlos

Carlos Pardo

Global Quality Manager

Master in Biochemistry, Molecular Biology and Biomedicine.

More than 10 years experience in Pharma Quality Systems.

Our team is specialized in the optimization and scale-up of laboratory methods into industrial processes for either bacteria, actinomycetes or fungi to produce different products: biomass, proteins, or small molecules.

The balanced team of upstream and downstream scientists thoroughly workon every stage of the process to optimize: the producing strain, the media, the seed train, the fermentation parameters, the titer, the product recovery process, the batch sizes, and, of course, the associated costs.

OUR KEY TO
YOUR SUCCESS

Your Idea is What Really Matters

Your Idea is What Really Matters

We will take care of your project as it would be our own, protecting its integrity and its scope throughout the process.

Feel the confidence of being in good hands

Feel the confidence of being in good hands

With more than 15 years of experience, our highly qualified team will work hand in hand with you to tailor an experimental design.

A dedicated project manager will walk you through the whole process.

Leave the optimization to us

Leave the optimization to us

Identyfing critical parameters, limiting factors and bottlenecks is our specialty.

Scale it up!

Scale it up!

From lab to pre-industrial stage, our in-house bioreactors will turn your idea into a real product ready for the next step.

Results is what you need

Results is what you need

We will deliver an easy to replicate, efficient and robust process.

Our Tech Transfer Dossier will guide you through every step.

We have your back

We have your back

You can count on our technucal support to follow your projects growth.

TECH TRANSFER PROGRESS

Cell Bank

2 Weeks
25%

Process & Analytical Transfer

3 Weeks
38%

Tech Transfer Batches

5-7 Weeks
63%

Batch Record & Purchasing

8 Weeks
100%

SUCCESS STORIES

BIOPROCESS SCALE-UP

PRODUCT:Protein
ORGANISM:Recombinant Bacterium
INITIAL TITRE:4-6 (OD)
FINAL TITRE:150-200 (OD)
KEY FOR SUCCESS:Fermentation Strategy
DSP STEPS:3

PROCESS OPTIMIZATION

PRODUCT:Siderophore
ORGANISM:Actinomycete
INITIAL TITRE:50 mg/L
FINAL TITRE:1500 mg/L
KEY FOR SUCCESS:Strain Selection & Medium composition
DSP STEPS:5

CUSTOM MANUFACTURING

PRODUCT:Macrolactone
ORGANISM:Filamentous fungi
INITIAL TITRE:140 mg/L
FINAL TITRE:800 mg/L
KEY FOR SUCCESS:Fermentation Media
DSP STEPS:5

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